Majority of Children With Type 1 Diabetes Produce and Deposit Anti-Tissue Transglutaminase Antibodies in the Small Intestine

@inproceedings{Maglio2009MajorityOC,
  title={Majority of Children With Type 1 Diabetes Produce and Deposit Anti-Tissue Transglutaminase Antibodies in the Small Intestine},
  author={M Maglio and Fiorella Florian and Monica Vecchiet and Renata Auricchio and Francesco Paparo and Raffaella Spadaro and Delia Zanzi and Luciano Rapacciuolo and Adriana Franzese and Daniele Sblattero and Roberto Marzari and Riccardo Troncone},
  booktitle={Diabetes},
  year={2009}
}
OBJECTIVE Anti-tissue transglutaminase (TG2) antibodies are the serological marker of celiac disease. Given the close association between celiac disease and type 1 diabetes, we investigated the production and deposition of anti-TG2 antibodies in the jejunal mucosa of type 1 diabetic children. RESEARCH DESIGN AND METHODS Intestinal biopsies were performed in 33 type 1 diabetic patients with a normal mucosal architecture: 14 had high levels (potential celiac disease patients) and 19 had normal… CONTINUE READING
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Increased density of jejunal T cells in patients having normal mucosa—marker of operative autoimmune mechanisms? Autoimmunity 1999;29:179–187 INTESTINAL ANTI-TG2 ANTIBODIES

  • S Iltanen, K Holm, J Partanen, P Laippala, M. Mäki
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  • 2009

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