Major surgical trauma induces proteolysis of insulin-like growth factor binding protein-3 in transgenic mice and is associated with a rapid increase in circulating levels of matrix metalloproteinase-9

@article{Belizon2006MajorST,
  title={Major surgical trauma induces proteolysis of insulin-like growth factor binding protein-3 in transgenic mice and is associated with a rapid increase in circulating levels of matrix metalloproteinase-9},
  author={Avraham Belizon and Irena Kirman and Erdinç Balik and Moshe Karten and Suvinit Jain and Richard Larry Whelan},
  journal={Surgical Endoscopy},
  year={2006},
  volume={21},
  pages={653-658}
}
BackgroundThe authors previously demonstrated a significant decrease in plasma levels of intact insulin-like growth factor binding protein-3 (IGFBP-3) after major open but not after laparoscopic-assisted surgery in humans. They postulated that this decrease may have an effect on postoperative tumor growth. It also has been shown that plasma levels of matrix metalloproteinase-9 (MMP-9), a protease capable of degrading IGFBP-3, are transiently increased after open colectomy in humans. The authors… CONTINUE READING
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