Major surface protein LipL32 is not required for either acute or chronic infection with Leptospira interrogans.

@article{Murray2009MajorSP,
  title={Major surface protein LipL32 is not required for either acute or chronic infection with Leptospira interrogans.},
  author={Gerald Laurence Murray and Amporn Srikram and David E. Hoke and Elsio A. Wunder and Rebekah Henry and Miranda C Y Lo and Kunkun Zhang and Rasana W Sermswan and Albert Icksang Ko and Ben Adler},
  journal={Infection and immunity},
  year={2009},
  volume={77 3},
  pages={952-8}
}
Leptospira interrogans is responsible for leptospirosis, a zoonosis of worldwide distribution. LipL32 is the major outer membrane protein of pathogenic leptospires, accounting for up to 75% of total outer membrane protein. In recent times LipL32 has become the focus of intense study because of its surface location, dominance in the host immune response, and conservation among pathogenic species. In this study, an lipL32 mutant was constructed in L. interrogans using transposon mutagenesis. The… CONTINUE READING
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