Major source of antigenic peptides for the MHC class I pathway is produced during the pioneer round of mRNA translation.

@article{Apcher2011MajorSO,
  title={Major source of antigenic peptides for the MHC class I pathway is produced during the pioneer round of mRNA translation.},
  author={S{\'e}bastien Apcher and Chrysoula Daskalogianni and Fabrice Lejeune and B{\'e}n{\'e}dicte Manoury and Gabriela Imhoos and Lea Heslop and Robin Fahraeus},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 28},
  pages={11572-7}
}
The MHC class I antigen presentation pathway allows the immune system to distinguish between self and nonself. Despite extensive research on the processing of antigenic peptides, little is known about their origin. Here, we show that mRNAs carrying premature stop codons that prevent the production of full-length proteins via the nonsense-mediated decay pathway still produce a majority of peptide substrates for the MHC class I pathway by a noncanonical mRNA translation process. Blocking the… CONTINUE READING