Major role of collagen IIB in the elevation of total type II procollagen messenger RNA in the hypertrophic phase of experimental osteoarthritis.

@article{Matyas1997MajorRO,
  title={Major role of collagen IIB in the elevation of total type II procollagen messenger RNA in the hypertrophic phase of experimental osteoarthritis.},
  author={John R Matyas and Mark E. Adams and Dingqiu Huang and Linda j. Sandell},
  journal={Arthritis and rheumatism},
  year={1997},
  volume={40 6},
  pages={
          1046-9
        }
}
OBJECTIVE To define the relative contributions of procollagen IIA and IIB messenger RNA (mRNA) in the 8-fold elevation of total (IIA + IIB) type II procollagen mRNA in cartilage from joints with early experimental osteoarthritis (OA). METHODS Unilateral cruciate ligament transection was performed on skeletally mature animals. Total RNA was extracted from articular cartilage from control joints and from joints with experimental OA. Northern blot hybridization with oligoprobes was used to… CONTINUE READING