Major role for cysteine proteases during the early phase of Acanthamoeba castellanii encystment.

@article{Leitsch2010MajorRF,
  title={Major role for cysteine proteases during the early phase of Acanthamoeba castellanii encystment.},
  author={David Leitsch and Martina Koehsler and Martina Marchetti-Deschmann and Andrea Deutsch and G{\"u}nter Allmaier and Michael Duch{\^e}ne and Julia Walochnik},
  journal={Eukaryotic cell},
  year={2010},
  volume={9 4},
  pages={611-8}
}
Acanthamoeba castellanii is a facultative pathogen that has a two-stage life cycle comprising the vegetatively growing trophozoite stage and the dormant cyst stage. Cysts are formed when the cell encounters unfavorable conditions, such as environmental stress or food deprivation. Due to their rigid double-layered wall, Acanthamoeba cysts are highly resistant to antiamoebic drugs. This is problematic as cysts can survive initially successful chemotherapeutic treatment and cause relapse of the… CONTINUE READING

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Growth on human cell layers reactivates attenuated properties after prolonged axenic culture

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