Major reorganization of immunoglobulin VH segmental elements during vertebrate evolution

@article{Hinds1986MajorRO,
  title={Major reorganization of immunoglobulin VH segmental elements during vertebrate evolution},
  author={Kerstin Hinds and Gary W. Litman},
  journal={Nature},
  year={1986},
  volume={320},
  pages={546-549}
}
In mammals, the immunoglobulin heavy-chain variable region (VH) locus is organized in a linear fashion; individual VH, diversity (DH), joining (JH) and constant (CH) region segments are linked in separate regions1. During somatic development, coding segments flanked by characteristic short recombination signal sequences, separated by intervening sequence regions that may exceed 2,000 kilobases (kb), are recombined. Combinatorial joining of different segments as well as imprecision in this… CONTINUE READING

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