Major quantitative trait locus on chromosome 2 for glucose tolerance in diabetic SMXA-5 mouse established from non-diabetic SM/J and A/J strains

@article{Kobayashi2005MajorQT,
  title={Major quantitative trait locus on chromosome 2 for glucose tolerance in diabetic SMXA-5 mouse established from non-diabetic SM/J and A/J strains},
  author={Misato Kobayashi and Fusayo Io and Takahiro Kawai and Mayumi Kumazawa and Hiroshi Ikegami and Masahiko Nishimura and Tamio Ohno and Fumihiko Horio},
  journal={Diabetologia},
  year={2005},
  volume={49},
  pages={486-495}
}
The SMXA-5 mouse is one of the SMXA recombinant inbred substrains established from the non-diabetic SM/J and A/J strains, and is a model for polygenic type 2 diabetes, characterised by moderately impaired glucose tolerance and hyperinsulinaemia. These diabetic traits are worsened by feeding a high-fat diet. The aim of this study was to dissect the diabetogenic loci in the A/J regions of the SMXA-5 genome that contribute to diabetes-related traits. We analysed the quantitative trait loci (QTL… CONTINUE READING

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