Major nutritional issues in the management of Parkinson's disease

  title={Major nutritional issues in the management of Parkinson's disease},
  author={Michela Barichella and Emanuele Cereda and Gianni Pezzoli},
  journal={Movement Disorders},
As with other neurodegenerative diseases, neurologic and nutritional elements may interact affecting each other in Parkinson's disease (PD). However, the long‐term effects of such interactions on prognosis and outcome have not been given much attention and are poorly addressed by current research. Factors contributing to the clinical conditions of patients with PD are not only the basic features of PD, progression of disease, and the therapeutic approach but also fiber and nutrient intakes (in… 
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It is demonstrated that disease duration, severity of motor and psychiatric symptoms (depression, anxiety, and fatigue) and fatigue are associated with nutritional status in PD.
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Together, protein-restricted diets are an effective approach to improve motor fluctuations in PD patients, while long-term adherence to these diets requires monitoring for side effects.
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It is demonstrated that patients with advanced stage MSA may develop malnutrition in the absence of a decrease in BMI, and serum albumin level may be useful for evaluating nutritional changes in MSA patients.
What increases the risk of malnutrition in Parkinson's disease?


Impact of nutritional status on the evolution of Alzheimer's disease and on response to acetylcholinesterase inhibitor treatment.
It is indicated that AD patients living at home with a caregiver are frequently at risk of undernutrition, and undernourished patients appear to be those who best respond to AChEI treatment.
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Weight loss in Parkinson’s disease
Attention must be paid as well to motor symptoms to prevent or reverse weight loss in PD patients, and to enhance glucose metabolism resulting in enhanced energy expenditure.
Diet, body size and micronutrient status in Parkinson's disease.
Nutritional status was assessed in a group of patients with Parkinson's disease. Weight loss since the onset of disease occurred in 52% of the patients and 22% had lost more than 12.8 kg. Although
A study of the nutritional status of elderly patients with Parkinson's disease.
Dietary analysis showed a higher daily intake of calories in the patients which was derived from an increased carbohydrate intake, and Parkinson's disease patients lose weight in spite of an increased calorie intake.
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An overview on epidemiological studies addressing a possible relation of dietary compounds and the risk for Parkinson’s disease is given.
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Avoidance of solid food in weight losing older patients with Parkinson's disease.
Parkinson's disease patients with weight loss seemed to avoid solid food, partly because of eating difficulties, but weight loss was associated with female gender, eating difficulties related to activities of daily living and preference towards soft food, but negatively correlated with age.
Effect of daytime protein restriction on nutrient intakes of free-living Parkinson's disease patients.
It is concluded that healthy and highly motivated patients can maintain adequate intakes of most nutrients while restricting daytime protein intake, however, nutrient intakes might be compromised in patients whose regular diets are marginally adequate.
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