Major injury leads to predominance of the T helper-2 lymphocyte phenotype and diminished interleukin-12 production associated with decreased resistance to infection.

@article{OSullivan1995MajorIL,
  title={Major injury leads to predominance of the T helper-2 lymphocyte phenotype and diminished interleukin-12 production associated with decreased resistance to infection.},
  author={Suzanne O'Sullivan and James A. Lederer and Andrea Horgan and David W. H. Chin and John A. Mannick and Mary L. Rodrick},
  journal={Annals of surgery},
  year={1995},
  volume={222 4},
  pages={482-90; discussion 490-2}
}
OBJECTIVE Patients with serious traumatic injury and major burns and an animal model of burn injury were studied to determine the effect of injury on the production of cytokines typical of the T helper-2 lymphocyte phenotype as opposed to the T helper-1 phenotype and on the production of interleukin-12. SUMMARY BACKGROUND DATA Perturbations of natural and adoptive immunity are related to the increased susceptibility to infection manifested by seriously injured and burn patients. Earlier work… CONTINUE READING

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