Major increases in opioid analgesic abuse in the United States: concerns and strategies.

@article{Compton2006MajorII,
  title={Major increases in opioid analgesic abuse in the United States: concerns and strategies.},
  author={Wilson M. Compton and Nora D. Volkow},
  journal={Drug and alcohol dependence},
  year={2006},
  volume={81 2},
  pages={
          103-7
        }
}
Challenges in the Development of Prescription Opioid Abuse-deterrent Formulations
TLDR
This manuscript captures the main consensus opinions of experts on opioid abuse and diversion, and information gleaned from a review of the relevant published literature, to identify major impediments to the development of opioid abuse-deterrent formulations and offer strategies that may accelerate their commercialization.
Opioid pharmaceuticals and addiction: the issues, and research directions seeking solutions.
Addressing the intersecting problems of opioid misuse and chronic pain treatment.
TLDR
Analysis of the 2006 National Survey of Drug Use and Health indicates the increasing prevalence of prescription opioid misuse is associated more with an increase in the general availability of these medications than misuse of the medications by those who were directly prescribed them.
Opioids and the treatment of chronic pain: controversies, current status, and future directions.
TLDR
A narrative review briefly describes the neurobiology of opioids and focuses on the complex issues at this interface between analgesia and abuse, including terminology, clinical challenges, and the potential for new agents, such as buprenorphine, to influence practice.
Pharmacokinetic and pharmacodynamic considerations in developing a response to the opioid epidemic
TLDR
The pathology and factors underlying opioid abuse are discussed, including pharmacokinetic and pharmacodynamic properties affecting abuse liability of commonly abused opioids, which inform the development of ideal abuse deterrent products.
The Opioid Epidemic: Crisis and Solutions.
  • P. Skolnick
  • Medicine
    Annual review of pharmacology and toxicology
  • 2018
TLDR
The development of effective alternatives to opioids, enabled at least in part by a fuller understanding of the neurobiological bases of pain, offers the best long-term solution for controlling and ultimately eradicating this epidemic.
Reflections on the role of opioids in the treatment of chronic pain: a shared solution for prescription opioid abuse and pain
TLDR
‘The Role of Opioids in the Treatment of Chronic Pain’ was the title of a recent workshop that highlights the relevance and urgency of the topic and the lack of understanding about opioid abuse potential and the risk of addiction in healthcare settings.
Opioid use and abuse: is there a problem?
TLDR
A comprehensive approach with the involvement of the industry been the corner stone of successful commercialization of abuse deterrent formulations is suggested and it is, indeed, only through such an approach with all stakeholders on the table that some of the problems relating to these valuable drugs, can be addressed.
Adverse Effects of Opioid Dependency on Central and Peripheral Aspects of the Neuromuscular System
TLDR
The current national crisis involving opioid dependency and drug overdose are growing problems that need to be addressed and opioids are one of the most widely prescribed class of drugs in the US based on a nationally-representative telephone survey.
Neurobiological Studies of Addiction in Chronic Pain States
TLDR
It is suggested that chronic pain is a generic term that refers to a broad spectrum of painful conditions; these pain conditions may have common neurobiological mechanisms, but also key distinctions, which may help to better predict the therapeutic window and side effect risks associated with chronic opioid therapy.
...
...

References

SHOWING 1-10 OF 37 REFERENCES
Trends in medical use and abuse of opioid analgesics.
TLDR
The trend of increasing medical use of opioid analgesics to treat pain does not appear to contribute to increases in the health consequences of opioids abuse, and the trend in medical use and abuse of these drugs is unchanged.
Drug Abuse, Dependence, and Addiction in Chronic Pain Patients
TLDR
It is concluded that these diagnoses occur in a significant percentage of chronic pain patients, and there is little evidence in these studies that addictive behaviors are common within the chronic pain population.
A survey of chronic noncancer pain patients prescribed opioid analgesics.
TLDR
It is indicated that opioid therapy for CNCP does not necessarily lead to problematic drug use, and some problematic side effects are likely to be surmountable through appropriate prescribing.
The impact of the addition of naloxone on the use and abuse of pentazocine.
TLDR
The Drug Abuse Warning Network (DAWN) of the National Institute of Drug Abuse and IMS America's National Prescription Audit were used to review the use and abuse patterns of pentazocine before and after the naloxone intervention.
Behavioral Monitoring and Urine Toxicology Testing in Patients Receiving Long-Term Opioid Therapy
TLDR
Requiring a report of behavioral issues and urine toxicology screens for patients receiving chronic opioids creates a more comprehensive monitoring system than either alone.
Cannabinoids and pain
TLDR
This review will focus on the endocannabinoid system in relation to pain transmission and the evidence for a role in both animal pain models and human studies performed to date.
Comparative Epidemiology of Dependence on Tobacco , Alcohol , Controlled Substances , and Inhalants : Basic Findings From the National Comorbidity Survey
TLDR
Many more Americans age 15-54 have been affected by dependence on psychoactive substances than by other psychiatric disturbances now accorded a higher priority in mental health service delivery systems, prevention, and sponsored research programs.
Variables that affect the clinical use and abuse of methylphenidate in the treatment of ADHD.
TLDR
The characteristics of clinical use (low doses administered orally and titrated for therapeutic effects) constrain methylphenidate's abuse.
Characterizing the subjective, psychomotor, and physiological effects of oral oxycodone in non-drug-abusing volunteers
TLDR
Although oxycodone produced abuse liability-related subjective effects, it also produced unpleasant effects, a phenomenon the authors have observed in other opioid studies in non-drug-abusing volunteers.
...
...