Major histocompatibility locus genetic markers of beryllium sensitization and disease.

  title={Major histocompatibility locus genetic markers of beryllium sensitization and disease.},
  author={Cesare Saltini and Luca Richeldi and Monica Losi and M Amicosante and C Voorter and Ella P M van den Berg-Loonen and Raed A Dweik and Herbert P Wiedemann and David C. Deubner and Carmine Tinelli},
  journal={The European respiratory journal},
  volume={18 4},
Hypersensitivity to beryllium (Be) is found in 1-16% of exposed workers undergoing immunological screening for beryllium disease using the beryllium lymphocyte proliferation test (BeLPT). However, only approximately 50% of BeLPT-positive workers present with lung granulomas (i.e. berylliosis). As berylliosis is associated with the human leukocyte antigen (HLA)-DP supratypic marker DPGlu69, the authors asked whether this marker is differentially associated with disease presentation. A population… CONTINUE READING
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