Major histocompatibility complex-linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice.

@article{Boehmer1978MajorHC,
  title={Major histocompatibility complex-linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice.},
  author={Harald von Boehmer and Werner Haas and Niels K. Jerne},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1978},
  volume={75 5},
  pages={2439-42}
}
Female murine T cells can respond to the Y antigen of male cells by generating cytotoxic T-killer lymphocytes. Responsiveness is linked to several H-2 genes. Two types of low responders can be distinguished: the B10.A(5R) (H-2i5) strain, a low responder because it lacks Y-specific precursor T cells able to differentiate into cytotoxic T-killer cells; and the CBA/J (H-2k) strain, a low responder because it lacks Y-specific T-helper cells able to support differentiation of T-killer cell… CONTINUE READING

From This Paper

Topics from this paper.
63 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 63 extracted citations

Similar Papers

Loading similar papers…