Major histocompatibility complex control of the class of the immune response to the hapten trinitrophenyl.

@article{Dieli1995MajorHC,
  title={Major histocompatibility complex control of the class of the immune response to the hapten trinitrophenyl.},
  author={Francesco Dieli and Geoffrey L. Asherson and Cesira Tiziana Bonanno and Guido Sireci and Alfredo Salerno},
  journal={Immunology},
  year={1995},
  volume={84 3},
  pages={355-9}
}
This paper investigates major histocompatibility complex (MHC) regulation of the class of the immune response given in vitro and in vivo following immunization of the congenic BALB/k (H-2k) and BALB/c (H-2d) mice with the hapten trinitrophenyl (TNP). TNP-immune lymph node cells from BALB/k mice produced high levels of interferon-gamma (IFN-gamma), interleukin-5 (IL-5) and IL-2 when stimulated with TNP-antigen-presenting cells (APC) in vitro, while TNP-immune lymph node cells from BALB/c mice… CONTINUE READING