Major histocompatibility complex class III genes and susceptibility to immunoglobulin A deficiency and common variable immunodeficiency.

@article{Volanakis1992MajorHC,
  title={Major histocompatibility complex class III genes and susceptibility to immunoglobulin A deficiency and common variable immunodeficiency.},
  author={John E. Volanakis and Z B Zhu and Fred M. Schaffer and Kevin Macon and John Palermos and Bruce O. Barger and Rodney C. Go and Robert D. Campbell and Harry W. Schroeder and Max D. Cooper},
  journal={The Journal of clinical investigation},
  year={1992},
  volume={89 6},
  pages={1914-22}
}
We have proposed that significant subsets of individuals with IgA deficiency (IgA-D) and common variable immunodeficiency (CVID) may represent polar ends of a clinical spectrum reflecting a single underlying genetic defect. This proposal was supported by our finding that individuals with these immunodeficiencies have in common a high incidence of C4A gene… CONTINUE READING