Major histocompatibility complex class II molecules induce the formation of endocytic MIIC-like structures

@article{Calafat1994MajorHC,
  title={Major histocompatibility complex class II molecules induce the formation of endocytic MIIC-like structures},
  author={Jero Calafat and Miranda Nijenhuis and Hans W. R. M. Janssen and A. J. Tulp and Simone Dusseljee and Richard W. Wubbolts and Jacques Neefjes},
  journal={The Journal of Cell Biology},
  year={1994},
  volume={126},
  pages={967 - 977}
}
During biosynthesis, major histochompatibility complex class II molecules are transported to the cell surface through a late endocytic multilaminar structure with lysosomal characteristics. This structure did not resemble any of the previously described endosomal compartments and was termed MIIC. We show here that continuous protein synthesis is required for the maintenance of MIIC in B cells. Transfection of class II molecules in human embryonal kidney cells induces the formation of… CONTINUE READING

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