Major histocompatibility complex class I allele-specific peptide libraries: identification of peptides that mimic an H-Y T cell epitope.

@article{Gavin1994MajorHC,
  title={Major histocompatibility complex class I allele-specific peptide libraries: identification of peptides that mimic an H-Y T cell epitope.},
  author={Marc A. Gavin and B Dere and Andres G Grandea and Kristin A Hogquist and Michael J. Bevan},
  journal={European journal of immunology},
  year={1994},
  volume={24 9},
  pages={2124-33}
}
We describe a novel method for screening large libraries of random peptides for T cell antigens. Two libraries were constructed, containing fixed amino acids representing the major histocompatibility complex (MHC) class I anchor residues for H-2Kb-restricted octamers and H-2Db-restricted nonamers. Peptides from the Kb-restricted library (KbL: SXIXFXXL) and the Db-restricted library (DbL: XXXXNXXXIM) specifically stabilize empty Kb and Db molecules, respectively. The libraries contain peptides… CONTINUE READING

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