Major histocompatibility complex class I gene expression in rat thyroid cells is regulated by hormones, methimazole, and iodide as well as interferon.

@article{Saji1992MajorHC,
  title={Major histocompatibility complex class I gene expression in rat thyroid cells is regulated by hormones, methimazole, and iodide as well as interferon.},
  author={Motoyasu Saji and James Moriarty and Tadanobu Ban and Dinah Singer and Leonard D. Kohn},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1992},
  volume={75 3},
  pages={871-8}
}
Autoimmune thyroid disease is associated with enhanced expression of major histocompatibility complex class I antigens on thyrocytes. To better understand this phenomenon, we have studied the normal expression of class I genes in FRTL-5 rat thyroid cells. A variety of hormones and growth factors that regulate the growth and function of these thyroid cells were found to decrease class I RNA levels: serum, insulin or insulin-like growth factor-I (IGF-I), and hydrocortisone. Antibody preparations… CONTINUE READING

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