Major histocompatibility complex class I diversity limits the repertoire of T cell receptors.

@article{Migalska2019MajorHC,
  title={Major histocompatibility complex class I diversity limits the repertoire of T cell receptors.},
  author={Magdalena Migalska and Alvaro San Sebasti{\'a}n and Jacek Radwan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2019},
  volume={116 11},
  pages={
          5021-5026
        }
}
Major histocompatibility complex (MHC) genes encode proteins that initiate adaptive immune responses through the presentation of foreign antigens to T cells. The high polymorphism found at these genes, thought to be promoted and maintained by pathogen-mediated selection, contrasts with the limited number of MHC loci found in most vertebrates. Although expressing many diverse MHC genes should broaden the range of detectable pathogens, it has been hypothesized to also cause deletion of larger… CONTINUE READING