Major histocompatibility complex and alveolar epithelial apoptosis in idiopathic pulmonary fibrosis

@article{FalfnValencia2005MajorHC,
  title={Major histocompatibility complex and alveolar epithelial apoptosis in idiopathic pulmonary fibrosis},
  author={Ramc{\'e}s Falf{\'a}n-Valencia and {\'A}ngel Eduardo Camarena and Armida Ju{\'a}rez and Carina Becerril and Martha Monta{\~n}o and Jose Cisneros and Felipe Mendoza and J. Javier Rainer Granados and Annie Pardo and Mois{\'e}s Selman},
  journal={Human Genetics},
  year={2005},
  volume={118},
  pages={235-244}
}
Idiopathic pulmonary fibrosis (IPF) is a chronic disease characterized by fibroblast expansion, and tissue remodeling. It is considered a multifactorial disease but the possible involved genes are largely unknown. Interestingly, studies regarding the possible role of major histocompatibility complex (MHC) are scanty and show contradictory results. In this study, we evaluated the polymorphisms of the MHC, locus HLA-B, -DRB1, and -DQB1 in a cohort of 75 IPF patients and 95 controls by using PCR… CONTINUE READING