Major expansion of CD8+ T cells with a predominant Vβ usage during the primary immune response to HIV

@article{Pantaleo1994MajorEO,
  title={Major expansion of CD8+ T cells with a predominant Vβ usage during the primary immune response to HIV},
  author={Giuseppe Pantaleo and James F. Demarest and Hugo Soudeyns and Cecilia Graziosi and François Denis and Joseph W. Adelsberger and Persephone Borrow and Michael S Saag and George M. Shaw and Rafick P. Sekalytt and Anthony S. Fauci},
  journal={Nature},
  year={1994},
  volume={370},
  pages={463-467}
}
A SIGNIFICANT proportion (up to 70%) of individuals experience an acute clinical syndrome of varying severity associated with primary infection with the human immunodeficiency virus (HIV)1–4. We report here studies on six individuals who showed an acute HIV syndrome which generally resolved within four weeks, concomitant with a dramatic downregulation of viraemia2–5. To characterize the T-cell-mediated primary immune response to HIV, we used combined semiquantitative polymerase chain reaction… CONTINUE READING