Major differences in Ca2+i response to anoxia between neonatal and adult rat CA1 neurons: role of Ca2+o and Na+o.

@article{Friedman1993MajorDI,
  title={Major differences in Ca2+i response to anoxia between neonatal and adult rat CA1 neurons: role of Ca2+o and Na+o.},
  author={Jonathan E. Friedman and Gabriel G. Haddad},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1993},
  volume={13 1},
  pages={63-72}
}
Although we and others have previously shown that newborn central mammalian neurons are more tolerant to anoxia than their adult counterparts, we do not know whether neonatal nerve cells accumulate free cytosolic calcium (Ca2+i) less than adults in response to O2 deprivation. In order to determine whether anoxia increases Ca2+i in adult and neonatal neurons, we monitored calcium in CA1 hippocampal neurons using the calcium-sensitive probe fluo-3 and confocal microscopy. These neurons were… CONTINUE READING