Major conformational changes during T7RNAP transcription initiation coincide with, and are required for, promoter release.

@article{Guo2005MajorCC,
  title={Major conformational changes during T7RNAP transcription initiation coincide with, and are required for, promoter release.},
  author={Qing Yang Guo and Dhananjaya Nayak and Luis G Brieba and Rui Sousa},
  journal={Journal of molecular biology},
  year={2005},
  volume={353 2},
  pages={256-70}
}
During transcription initiation conformational changes in the transcriptional machinery are required to accommodate the growing RNA, to allow the polymerase to release the promoter, and to endow the elongation complex with high processivity. In T7 RNA polymerase these changes involve refolding and reorientation of elements of the N-terminal domain, as well as changes in how the DNA is bound within the complex. However, when and where these conformational changes occur is unknown, and the role… CONTINUE READING

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