Major birth defects among infants with Down syndrome in Alexandria, Egypt (1995-2000): trends and risk factors.

@article{Mokhtar2001MajorBD,
  title={Major birth defects among infants with Down syndrome in Alexandria, Egypt (1995-2000): trends and risk factors.},
  author={Mohamed Mohamed Mokhtar and M. R. Abdel-fattah},
  journal={Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit},
  year={2001},
  volume={7 3},
  pages={441-51}
}
We evaluated the hypothesis that the trisomy 21 genome interacts with environmental factors during early pregnancy to increase the risk for birth anomalies in Down syndrome infants in Alexandria, Egypt. A case-control study on 514 infants with confirmed Down syndrome was carried out from 1 July 1995 to 30 June 2000. Genetic, biological, environmental and reproductive factors were analysed. Multiple logistic regression analysis showed the following factors to be independently associated with… CONTINUE READING

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