Major biological actions of CCK – a critical evaluation of research findings

  title={Major biological actions of CCK – a critical evaluation of research findings},
  author={Heidrun Fink and Andre Rex and Mechthild Voits and J{\"o}rg-Peter Voigt},
  journal={Experimental Brain Research},
  • H. FinkA. Rex J. Voigt
  • Published 23 October 1998
  • Biology, Psychology
  • Experimental Brain Research
Abstract Cholecystokinin (CCK) is one of the first discovered gastrointestinal hormones and one of the most abundant neuropeptides in the brain. Two types of CCK receptors have been identified: (1) CCK-A receptors are mainly located in the periphery, but are also found in some areas of the CNS; and (2) CCK-B receptors are widely distributed in the brain. Major biological actions of CCK are the reduction of food intake and the induction of anxiety-related behavior. Inhibition of feeding is… 

Therapeutic and chemical developments of cholecystokinin receptor ligands

The main biological role of CCK, the therapeutic potential ofCCK-A and CCK-B receptor agonists and antagonists and the common compounds from the different families of ligands are reviewed.

Elevated cholecystokininergic tone constitutes an important molecular/neuronal mechanism for the expression of anxiety in the mouse.

It is shown that overexpression of the CC KR-2 in neurons of the forebrain significantly increases CCKR-2 binding capacity in tg mice compared with their littermate controls, and this study has validated a robust genetic anxiety model in the mouse in terms of their face, constructive, and predictive validity.

SR146131, a cholecystokinin-A receptor agonist, antagonizes prepulse inhibition deficits produced by dizocilpine and DOI

The lack of an effect of SR146131 on amphetamine-induced disruption of PPI suggests that a selective nonpeptide CCK-A agonist may not produce antipsychotic-like effects on dopamine transmission, which is consistent with the effects of drugs that inhibit transmission in the 5HT2A receptor system, including atypical antipsychotics.

Cholecystokinin receptor subtypes: role in the modulation of anxiety-related and reward-related behaviours in animal models.

Evidence on the role of CCK in anxiety-related and reward-related behaviours in various animal models indicates that CCK-B receptors in the basolateral amygdala are important mediators of anxiety- related behaviours and thatCCK-A and CCK -B receptorsIn the nucleus accumbens are important in mediating different aspects of reward- related behaviour.

Differential effects to CCK-4-induced panic by dexamethasone and hydrocortisone

Findings suggest that CCK-4-induced stress hormone release seems susceptible to cortisol-feedback inhibition and argues for a suprapituitary site of CCK action.

Role of the amygdaloid cholecystokinin (CCK)/gastrin‐2 receptors and terminal networks in the modulation of anxiety in the rat. Effects of CCK‐4 and CCK‐8S on anxiety‐like behaviour and [3H]GABA release

It is suggested that CCK modulates glutamate‐GABA mechanisms by acting on CCK‐2 receptors via volume transmission occurring at the level of the basolateral amygdaloid nucleus and/or by synaptic or perisynaptic volume transmission in the region of the rostrolateral main and paracapsular intercalated islands, resulting in subsequent disinhibition of the central amygdala and anxiety or panic‐like behaviour.

Anxiogenic Effect of Cholecystokinin in the Dorsal Periaqueductal Gray

CCK-8s injected into the dPAG induced Fos immunoreactivity in several brain areas related to defensive behavior, including the PAG, median, and dorsal raphe nuclei, superior colliculus, lateral septaluclei, medial hypothalamus, and medial amygdala.



Biological actions of cholecystokinin

Role of cholecystokinin and opioid peptides in control of food intake.

An increasing body of evidence supports the concept that opioid and CCK peptides may interact to control food intake, but the evidence is more suggestive than conclusive.

Effects of Cholecystokinin-Receptor Agonists on Cortical 5-HT Release in Guinea Pigs on the X-Maze

CCK-8S Facilitates 5-HT Release in the Rat Hypothalamus

Comparison of the satiating effect of the CCKA receptor agonist A71378 with CCK-8S

Increased food intake after type A but not type B cholecystokinin receptor blockade

Type A CCK receptors mediate satiety effects of intestinal nutrients

The role of CCK, caerulein, and CCK antagonists in nociception

Neostriatal neurons of rats can be influenced by cholecystokinin-A receptor agonists