Major basic protein-1 promotes fibrosis of dystrophic muscle and attenuates the cellular immune response in muscular dystrophy.

Abstract

The immune response to dystrophin-deficient muscle promotes the pathology of Duchenne muscular dystrophy (DMD) and the mdx mouse model of DMD. In this investigation, we find that the release of major basic protein (MBP) by eosinophils is a prominent feature of DMD and mdx dystrophy and that eosinophils lyse muscle cells in vitro by the release of MBP-1. We… (More)
DOI: 10.1093/hmg/ddn129

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@article{WehlingHenricks2008MajorBP, title={Major basic protein-1 promotes fibrosis of dystrophic muscle and attenuates the cellular immune response in muscular dystrophy.}, author={Michelle Wehling-Henricks and Sophie Sokolow and Jamie J Lee and Kyu H Myung and S. Armando Villalta and James G. Tidball}, journal={Human molecular genetics}, year={2008}, volume={17 15}, pages={2280-92} }