Major Histocompatibility Complex Class I–restricted Cross-presentation Is Biased towards High Dose Antigens and Those Released during Cellular Destruction

@article{Kurts1998MajorHC,
  title={Major Histocompatibility Complex Class I–restricted Cross-presentation Is Biased towards High Dose Antigens and Those Released during Cellular Destruction },
  author={Christian Kurts and Jacques F. A. P. Miller and Rathan M. Subramaniam and Francis Robert Carbone and William R Heath},
  journal={The Journal of Experimental Medicine},
  year={1998},
  volume={188},
  pages={409 - 414}
}
Naive T cells recirculate mainly within the secondary lymphoid compartment, but once activated they can enter peripheral tissues and perform effector functions. To activate naive T cells, foreign antigens must traffic from the site of infection to the draining lymph nodes, where they can be presented by professional antigen presenting cells. For major histocompatibility complex class I-restricted presentation to CD8+ T cells, this can occur via the cross-presentation pathway. Here, we… CONTINUE READING