Major Hemorrhage and Tolerability of Warfarin in the First Year of Therapy Among Elderly Patients With Atrial Fibrillation

@article{Hylek2007MajorHA,
  title={Major Hemorrhage and Tolerability of Warfarin in the First Year of Therapy Among Elderly Patients With Atrial Fibrillation},
  author={E. Hylek and C. Evans-Molina and C. Shea and L. Henault and S. Regan},
  journal={Circulation},
  year={2007},
  volume={115},
  pages={2689-2696}
}
  • E. Hylek, C. Evans-Molina, +2 authors S. Regan
  • Published 2007
  • Medicine
  • Circulation
  • Background— Warfarin is effective in the prevention of stroke in atrial fibrillation but is under used in clinical care. Concerns exist that published rates of hemorrhage may not reflect real-world practice. Few patients ≥80 years of age were enrolled in trials, and studies of prevalent use largely reflect a warfarin-tolerant subset. We sought to define the tolerability of warfarin among an elderly inception cohort with atrial fibrillation. Methods and Results— Consecutive patients who started… CONTINUE READING
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    References

    SHOWING 1-10 OF 67 REFERENCES
    Risk Factors for Complications of Chronic Anticoagulation: A Multicenter Study
    • 667
    Effect of intensity of oral anticoagulation on stroke severity and mortality in atrial fibrillation.
    • 1,180