Major Evolutionary Transitions in Centromere Complexity

Abstract

Centromeres are chromosomal elements that are both necessary and sufficient for chromosome segregation. However, the puzzlingly broad range in centromere complexity, from simple "point" centromeres to multi-megabase arrays of DNA satellites, has defied explanation. We posit that ancestral centromeres were epigenetically defined and that point centromeres… (More)
DOI: 10.1016/j.cell.2009.08.036

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