Major Depression as a Neuroprogressive Prelude to Dementia: What Is the Evidence?

@article{Leonard2017MajorDA,
  title={Major Depression as a Neuroprogressive Prelude to Dementia: What Is the Evidence?},
  author={Brian E. Leonard},
  journal={Modern trends in pharmacopsychiatry},
  year={2017},
  volume={31},
  pages={
          56-66
        }
}
Epidemiological studies implicate chronic depression as a predisposing factor for dementia in later life. However, the link is incompletely understood and controversial. The aim of this review is to consider some of the biological factors that contribute to neuroprogressive brain dysfunction in late life as a consequence of prolonged, low-grade inflammation in the course of depressive episodes. As chronic inflammation is known to precipitate increased apoptosis of neurons and astrocytes, this… CONTINUE READING
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