Maitotoxin-induced myocardial cell injury: calcium accumulation followed by ATP depletion precedes cell death.

@article{Santostasi1990MaitotoxininducedMC,
  title={Maitotoxin-induced myocardial cell injury: calcium accumulation followed by ATP depletion precedes cell death.},
  author={Giovanni Santostasi and Rahul Krishnan Kutty and Antonio Luca Bartorelli and Takashi Yasumoto and Gopal Krishna},
  journal={Toxicology and applied pharmacology},
  year={1990},
  volume={102 1},
  pages={164-73}
}
Maitotoxin, the most potent marine toxin, is known to increase the uptake and the accumulation of Ca2+ into cells, and was used in the present study to investigate the mechanisms of myocardial cell damage induced by Ca2+ overload. In cultured cardiomyocytes, isolated from 2-day-old rats, maitotoxin affected cell viability, as indicated by the leakage of the cytosolic enzyme lactate dehydrogenase (LDH) and of radiolabeled adenine nucleotides into the extracellular medium. Maitotoxin-induced… CONTINUE READING
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