Maitotoxin converts the plasmalemmal Ca(2+) pump into a Ca(2+)-permeable nonselective cation channel.

@article{Sinkins2009MaitotoxinCT,
  title={Maitotoxin converts the plasmalemmal Ca(2+) pump into a Ca(2+)-permeable nonselective cation channel.},
  author={William G Sinkins and Mark Estacion and Vikram Prasad and Monu Goel and Gary E. Shull and Diana L. Kunze and William P. Schilling},
  journal={American journal of physiology. Cell physiology},
  year={2009},
  volume={297 6},
  pages={C1533-43}
}
Maitotoxin (MTX) activates Ca(2+)-permeable nonselective cation channels and causes a dramatic increase in cytosolic free Ca(2+) concentration ([Ca(2+)](i)) in every cell examined to date, but the molecular identity of the channels involved remains unknown. A clue came from studies of a structurally related marine toxin called palytoxin (PTX). PTX binds to the plasmalemmal Na(+)-K(+)-ATPase (NKA) and converts the Na(+) pump into a nonselective cation channel. Given the high permeability of the… CONTINUE READING
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Maitotoxin induces biphasic interleukin-1B secretion and membrane C1542 MTX-INDUCED PMCA CHANNELS AJP-Cell Physiol

  • PA Verhoef, SB Kertesy, M Estacion, WP Schilling, GR. Dubyak
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