Maintenance of vascular integrity in the embryo requires signaling through the fibroblast growth factor receptor.

@article{Lee2000MaintenanceOV,
  title={Maintenance of vascular integrity in the embryo requires signaling through the fibroblast growth factor receptor.},
  author={S H Lee and Dr. J. Schloss and J. L. Swain},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 43},
  pages={33679-87}
}
Basic fibroblast growth factor (FGF)-2 is important for vessel formation and/or maintenance of vascular integrity in the embryo. FGF signaling may be mediated through transmembrane tyrosine kinase receptors or directly through intracellular pathways that do not involve receptor activation. To determine the role of receptor-mediated signaling in endothelial cells, an adenovirus encoding truncated FGF receptor (FGFR)-1, under the control of the cytomegalovirus promoter, was expressed in… CONTINUE READING

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