Maintenance of trabecular structure and bone volume by vitamin K2 in mature rats with long-term tail suspension

@article{Iwasaki2002MaintenanceOT,
  title={Maintenance of trabecular structure and bone volume by vitamin K2 in mature rats with long-term tail suspension},
  author={Yoshiko Iwasaki and Hideyuki Yamato and Hisashi Murayama and Masami Sato and Takeshi Takahashi and Ikuko Ezawa and Kiyoshi Kurokawa and Masafumi Fukagawa},
  journal={Journal of Bone and Mineral Metabolism},
  year={2002},
  volume={20},
  pages={216-222}
}
 Bone volume loss is one of the major health problems during long-term spaceflight. We examined the effects of vitamin K2 on bone abnormalities in tail-suspended mature male Sprague-Dawley rats (13 weeks old). In this model, increased bone resorption and sustained suppression of bone formation resulted in progressive bone loss in 4 weeks, which simulates bone changes in humans during spaceflight. A significant decrease in bone mineral density (BMD), as well as a decreased mineral apposition… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

Soybean isoflavones preserve bone mass in hindlimb-unloaded mice

Journal of Bone and Mineral Metabolism • 2006
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 45 references

Effect of vitamin K2 on three-dimensional trabecular microarchitecture in ovariectomized rats.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research • 2000
View 1 Excerpt

Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research • 2000
View 1 Excerpt

Calcium metabolism before, during, and after a 3-mo spaceflight: kinetic and biochemical changes.

American journal of physiology. Regulatory, integrative and comparative physiology • 1999
View 3 Excerpts

Similar Papers

Loading similar papers…