Maintenance of the human malarial parasite, Plasmodium falciparum, in scid mice and transmission of gametocytes to mosquitoes

Abstract

The study of human malaria has been hampered by the lack of small animal models for the human-infecting malarial parasites. To approach this problem, the erythrocytic stages of the human malarial parasite Plasmodium falciparum were adapted to in vitro growth in the presence of ascites fluid from mice homozygous for the severe-combined immunodeficiency (scid… (More)

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@article{Moore1995MaintenanceOT, title={Maintenance of the human malarial parasite, Plasmodium falciparum, in scid mice and transmission of gametocytes to mosquitoes}, author={Jenna M. Moore and N K Shyam Kumar and Leonard D Shultz and Thiruchandurai V. Rajan}, journal={The Journal of Experimental Medicine}, year={1995}, volume={181}, pages={2265 - 2270} }