Maintenance of the hematopoietic stem cell pool in bone marrow niches by EVI1-regulated GPR56

@article{Saito2013MaintenanceOT,
  title={Maintenance of the hematopoietic stem cell pool in bone marrow niches by EVI1-regulated GPR56},
  author={Yoshiyuki Saito and Kazuko Kaneda and Akira Suekane and Emi Ichihara and Shingo Nakahata and Norio Yamakawa and Kazuhiro Nagai and Norikazu Mizuno and Kazuhiro Kogawa and Ikuo Miura and Hiromi Itoh and Kazuhiro Morishita},
  journal={Leukemia},
  year={2013},
  volume={27},
  pages={1637-1649}
}
Acute myeloid leukemia with high ecotropic viral integration site-1 expression (EVI1high AML) is classified as a refractory type of leukemia with a poor prognosis. To provide new insights into the prevention and treatment of this disease, we identified the high expression of EVI1-regulated G protein-coupled receptor 56 (GPR56), and the association of high cell adhesion and antiapoptotic activities in EVI1high AML cells. Knockdown of GPR56 expression decreased the cellular adhesion ability… CONTINUE READING
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