Maintenance of superior learning and memory function in NR2B transgenic mice during ageing

@article{Cao2007MaintenanceOS,
  title={Maintenance of superior learning and memory function in NR2B transgenic mice during ageing},
  author={Xiaohua Cao and Zhenzhong Cui and Ruiben Feng and Ya-ping Tang and Zhenxia Qin and Bing Mei and Joe Z. Tsien},
  journal={European Journal of Neuroscience},
  year={2007},
  volume={25}
}
Brain ageing represents a general and evolutionarily conserved phenomenon and is marked by gradual declines in cognitive functions such as learning and memory. As a synaptic coincidence detector, the N‐methyl‐d‐aspartate (NMDA) receptor is known to be essential for the induction of synaptic plasticity and memory formation. Here, we test the hypothesis that up‐regulation of NR2B expression is beneficial for learning and memory in the aged animals. Our in vitro recordings show that the aged… Expand
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  • Neuropharmacology
  • 2018
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