Maintenance of stemness is associated with the interation of LRP6 and heparin-binding protein CCN2 autocrined by hepatocellular carcinoma

@inproceedings{Jia2017MaintenanceOS,
  title={Maintenance of stemness is associated with the interation of LRP6 and heparin-binding protein CCN2 autocrined by hepatocellular carcinoma},
  author={Qing-an Jia and Yang Bu and Zhiming Wang and Bendong Chen and Qiangbo Zhang and Songning Yu and Qingguang Liu},
  booktitle={Journal of experimental & clinical cancer research : CR},
  year={2017}
}
BACKGROUND The overall response rate of hepatocellular carcinoma (HCC) to chemotherapy is poor. In our previous study, oxaliplatin-resistant HCC is found to exhibit an enhanced stemness, and increased levels of CCN2 and LRP6, while the role of CCN2 and LRP6 in the prognosis of HCC patients, and the interaction regulation mechanism between CCN2 and LRP6 are still unclear. METHODS The expression levels of CCN2 and LRP6 were detected in large cohorts of HCCs, and functional analyses of CCN2 and… CONTINUE READING
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