Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.

@article{Rowbotham2011MaintenanceOS,
  title={Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.},
  author={Samuel P Rowbotham and Leila Barki and Ana Neves-Costa and F{\'a}tima Aparecida dos Santos and Wendy Dean and Nicola A Hawkes and Parul Choudhary and William Ryan Will and Judith M. Webster and David Oxley and Catherine Green and Patrick Daniel Varga-Weisz and Jacqueline E. Mermoud},
  journal={Molecular cell},
  year={2011},
  volume={42 3},
  pages={285-96}
}
Epigenetic marks such as posttranslational histone modifications specify the functional states of underlying DNA sequences, though how they are maintained after their disruption during DNA replication remains a critical question. We identify the mammalian SWI/SNF-like protein SMARCAD1 as a key factor required for the re-establishment of repressive chromatin. The ATPase activity of SMARCAD1 is necessary for global deacetylation of histones H3/H4. In this way, SMARCAD1 promotes methylation of… CONTINUE READING