Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: Abnormal intestinal motility and the expression of cation transporters.

@article{Chen2001MaintenanceOS,
  title={Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: Abnormal intestinal motility and the expression of cation transporters.},
  author={J J Chen and Zengbiao Li and Hui Pan and Dennis L. Murphy and Hadassah Tamir and Hermann Koepsell and Michael David Gershon},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2001},
  volume={21 16},
  pages={6348-61}
}
The enteric serotonin reuptake transporter (SERT) has been proposed to play a critical role in serotonergic neurotransmission and in the initiation of peristaltic and secretory reflexes. We analyzed potential compensatory mechanisms and enteric function in the bowels of mice with a targeted deletion of SERT. The guts of these animals were found to lack mRNA encoding SERT; moreover, high-affinity uptake of 5-HT into epithelial cells, mast cells, and enteric neurons was present in the SERT… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 138 extracted citations

Reviews of Physiology, Biochemistry and Pharmacology

Reviews of Physiology, Biochemistry and Pharmacology • 2003
View 8 Excerpts
Highly Influenced

Origin of the blood hyperserotonemia of autism

Theoretical Biology and Medical Modelling • 2008
View 5 Excerpts
Highly Influenced

Physiological genomics of antidepressant targets: keeping the periphery in mind.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2001
View 6 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 103 references

Irritable bowel syndrome: disease definition and symptom description.

The European journal of surgery. Supplement. : = Acta chirurgica. Supplement • 1998
View 4 Excerpts
Highly Influenced

5-HT activates neural reflexes regulating secretion in the guinea-pig colon.

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society • 1997
View 4 Excerpts
Highly Influenced

Role for 5-HT and ACh in submucosal reflexes mediating colonic secretion.

The American journal of physiology • 1995
View 4 Excerpts
Highly Influenced

The enteric nervous system.

The American journal of gastroenterology • 1994
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…