Maintenance of oxidative phosphorylation protects cells from Actinobacillus actinomycetemcomitans leukotoxin-induced apoptosis.

@article{Yamaguchi2001MaintenanceOO,
  title={Maintenance of oxidative phosphorylation protects cells from Actinobacillus actinomycetemcomitans leukotoxin-induced apoptosis.},
  author={Noboru Yamaguchi and Irene R. Kieba and Jonathan M Korostoff and Pamela S. Howard and Bruce J. Shenker and Edward T. Lally},
  journal={Cellular microbiology},
  year={2001},
  volume={3 12},
  pages={811-23}
}
Subnanomolar concentrations (3 x 10(-10) M) of Actinobacillus actinomycetemcomitans leukotoxin (Ltx) trigger apoptosis of JY cells, as shown by a decrease in mitochondrial transmembrane potential (DeltaPsim), hyperproduction of reactive oxygen species (ROS) and release of cytochrome c from the intermembrane space. When compared with heat-inactivated… CONTINUE READING