Maintenance of muscle mass is not dependent on the calcineurin-NFAT pathway.

  title={Maintenance of muscle mass is not dependent on the calcineurin-NFAT pathway.},
  author={Esther E Dupont-Versteegden and Micheal Knox and Cathy M Gurley and John D. Houl{\'e} and Charlotte A. Peterson},
  journal={American journal of physiology. Cell physiology},
  volume={282 6},
In this study, the role of the calcineurin pathway in skeletal muscle atrophy and atrophy-reducing interventions was investigated in rat soleus muscles. Because calcineurin has been suggested to be involved in skeletal and cardiac muscle hypertrophy, we hypothesized that blocking calcineurin activity would eliminate beneficial effects of interventions that maintain muscle mass in the face of atrophy-inducing stimuli. Hindlimb suspension and spinal cord transection were used to induce atrophy… CONTINUE READING


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