Maintenance of immune tolerance by Foxp3+ regulatory T cells requires CD69 expression.

  title={Maintenance of immune tolerance by Foxp3+ regulatory T cells requires CD69 expression.},
  author={Jos{\'e} C. Romero Cort{\'e}s and Raquel S{\'a}nchez-D{\'i}az and Elena R. Bovolenta and Olga Barreiro and Sandra Lasarte and Adela Matesanz-Mar{\'i}n and Mar{\'i}a L Toribio and Francisco S{\'a}nchez-Madrid and Pilar Mart{\'i}n},
  journal={Journal of autoimmunity},
Although FoxP3(+) regulatory T cells are key players in the maintenance of immune tolerance and autoimmunity, the lack of specific markers constitute an obstacle to their use for immunotherapy protocols. In this study, we have investigated the role of the C-type lectin receptor CD69 in the suppressor function of Tregs and maintenance of immune tolerance towards harmless inhaled antigens. We identified a novel FoxP3(+)CD69(+) Treg subset capable to maintain immune tolerance and protect to… CONTINUE READING
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