Maintenance of heterochromatin by RNA interference of tandem repeats

  title={Maintenance of heterochromatin by RNA interference of tandem repeats},
  author={Robert A. Martienssen},
  journal={Nature Genetics},
Tandem repeats are prone to epigenetic silencing regulated by RNA interference. This may be because siRNAs from tandem array transcripts are regenerated by RNA-dependent RNA polymerase (RdRP) and Dicer, but siRNAs from single-copy sequences are exhausted by sequential use of downstream primers by RdRP. This could account for the formation of heterochromatin from tandem repeats. 

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