Maintenance of genomic integrity by p53: complementary roles for activated and non-activated p53

@article{Albrechtsen1999MaintenanceOG,
  title={Maintenance of genomic integrity by p53: complementary roles for activated and non-activated p53},
  author={Nils Albrechtsen and Irene Dornreiter and F. Grosse and Ella J Kim and Lisa Wiesm{\"u}ller and Wolfgang Deppert},
  journal={Oncogene},
  year={1999},
  volume={18},
  pages={7706-7717}
}
In this review we describe the multiple functions of p53 in response to DNA damage, with an emphasis on p53's role in DNA repair. We summarize data demonstrating that p53, through its various biochemical activities and via its ability to interact with components of the repair and recombination machinery, actively participates in various processes of DNA repair and DNA recombination. An important aspect in evaluating p53 functions arises from the finding that the p53 core domain harbors two… CONTINUE READING

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