Maintenance of genome stability in Saccharomyces cerevisiae.

@article{Kolodner2002MaintenanceOG,
  title={Maintenance of genome stability in Saccharomyces cerevisiae.},
  author={Richard D Kolodner and Christopher D. Putnam and Kyungjae Myung},
  journal={Science},
  year={2002},
  volume={297 5581},
  pages={552-7}
}
Most human cancer cells show signs of genome instability, ranging from elevated mutation rates to gross chromosomal rearrangements and alterations in chromosome number. Little is known about the molecular mechanisms that generate this instability or how it is suppressed in normal cells. Recent studies of the yeast Saccharomyces cerevisiae have begun to uncover the extensive and redundant pathways that keep the rate of genome rearrangements at very low levels. These studies, which we review here… CONTINUE READING