Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells

@article{Lee2006MaintenanceOC,
  title={Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells},
  author={J. Scott Lee and Ji-Hun Mo and Kyoko Katakura and Irit Alkalay and Adam N. Rucker and Yu-Tsueng Liu and Hyun-ku Lee and Carol Shen and Gady Cojocaru and Steve S Shenouda and Martin F. Kagnoff and Lars Eckmann and Yinon Ben-Neriah and Eyal Raz},
  journal={Nature Cell Biology},
  year={2006},
  volume={8},
  pages={1327-1336}
}
The mechanisms by which commensal bacteria suppress inflammatory signalling in the gut are still unclear. Here, we present a cellular mechanism whereby the polarity of intestinal epithelial cells (IECs) has a major role in colonic homeostasis. TLR9 activation through apical and basolateral surface domains have distinct transcriptional responses, evident by NF-κB activation and cDNA microarray analysis. Whereas basolateral TLR9 signals IκBα degradation and activation of the NF-κB pathway, apical… CONTINUE READING
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Toll-like receptor 9-induced type I IFN protects mice from experimental colitis

  • K Katakura
  • J. Clin. Invest
  • 2005

Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis

  • M Fukata
  • Am. J. Physiol. Gastrointest. Liver Physiol. 288,
  • 2005

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