Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells

@article{Lee2006MaintenanceOC,
  title={Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells},
  author={Jongdae Lee and Ji-Hun Mo and K. Katakura and I. Alkalay and Adam N Rucker and Y. Liu and Hyun-ku Lee and C. Shen and G. Cojocaru and Steve Shenouda and M. Kagnoff and L. Eckmann and Y. Ben-Neriah and E. Raz},
  journal={Nature Cell Biology},
  year={2006},
  volume={8},
  pages={1327-1336}
}
  • Jongdae Lee, Ji-Hun Mo, +11 authors E. Raz
  • Published 2006
  • Medicine, Biology
  • Nature Cell Biology
  • The mechanisms by which commensal bacteria suppress inflammatory signalling in the gut are still unclear. [...] Key Result TLR9 activation through apical and basolateral surface domains have distinct transcriptional responses, evident by NF-κB activation and cDNA microarray analysis. Whereas basolateral TLR9 signals IκBα degradation and activation of the NF-κB pathway, apical TLR9 stimulation invokes a unique response in which ubiquitinated IκB accumulates in the cytoplasm preventing NF-κB activation…Expand Abstract

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