Maintenance of a bone collagen phenotype by osteoblast-like cells in 3D periodic porous titanium (Ti-6Al-4 V) structures fabricated by selective electron beam melting.

@article{Hrabe2013MaintenanceOA,
  title={Maintenance of a bone collagen phenotype by osteoblast-like cells in 3D periodic porous titanium (Ti-6Al-4 V) structures fabricated by selective electron beam melting.},
  author={Nikolas W Hrabe and Peter Heinl and Rajendra K. Bordia and Carolin K{\"o}rner and Russell J. Fernandes},
  journal={Connective tissue research},
  year={2013},
  volume={54 6},
  pages={351-60}
}
Regular 3D periodic porous Ti-6Al-4 V structures were fabricated by the selective electron beam melting method (EBM) over a range of relative densities (0.17-0.40) and pore sizes (500-1500 µm). Structures were seeded with human osteoblast-like cells (SAOS-2) and cultured for four weeks. Cells multiplied within these structures and extracellular matrix collagen content increased. Type I and type V collagens typically synthesized by osteoblasts were deposited in the newly formed matrix with time… CONTINUE READING
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