Maintenance of T cell function in the face of chronic antigen stimulation and repeated reactivation for a latent virus infection.

@article{Mackay2012MaintenanceOT,
  title={Maintenance of T cell function in the face of chronic antigen stimulation and repeated reactivation for a latent virus infection.},
  author={Laura K Mackay and Linda M Wakim and Catherine J van Vliet and Claerwen M Jones and Scott N Mueller and Oliver M Bannard and Douglas T Fearon and William R Heath and Francis Robert Carbone},
  journal={Journal of immunology},
  year={2012},
  volume={188 5},
  pages={2173-8}
}
Persisting infections are often associated with chronic T cell activation. For certain pathogens, this can lead to T cell exhaustion and survival of what is otherwise a cleared infection. In contrast, for herpesviruses, T cells never eliminate infection once it is established. Instead, effective immunity appears to maintain these pathogens in a state of latency. We used infection with HSV to examine whether effector-type T cells undergoing chronic stimulation retained functional and… CONTINUE READING

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