Maintenance of Hypertensive Hemodynamics Does Not Depend on ROS in Established Experimental Chronic Kidney Disease

@inproceedings{Papazova2014MaintenanceOH,
  title={Maintenance of Hypertensive Hemodynamics Does Not Depend on ROS in Established Experimental Chronic Kidney Disease},
  author={Diana A Papazova and Arianne van Koppen and Maarten P. Koeners and Ronald L. A. W. Bleys and Marianne C Verhaar and Jaap A. Joles},
  booktitle={PloS one},
  year={2014}
}
While the presence of oxidative stress in chronic kidney disease (CKD) is well established, its relation to hypertensive renal hemodynamics remains unclear. We hypothesized that once CKD is established blood pressure and renal vascular resistance (RVR) no longer depend on reactive oxygen species. CKD was induced by bilateral ablation of 2/3 of each kidney. Compared to age-matched, sham-operated controls all ablated rats showed proteinuria, decreased glomerular filtration rate (GFR), more renal… CONTINUE READING
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